Heart valve prostheses having multiple support arms and methods for percutaneous heart valve replacement

A heart valve repair device, comprising:

• a support having an upstream end and a downstream end with respect to a longitudinal axis of the support;
• a radially-extending segment extending outwardly from the upstream end of the support and having a generally circular cross-section shape, wherein the radially-extending segment includes a plurality of interconnected self-expanding struts, and wherein the radially-extending segment is configured to expand within an atrial space proximate to an annulus of a mitral valve to engage supra-annular tissue;
• and
• a leaflet capture arm having at least a portion extending from the downstream end of the support in a radially outward and upstream direction,
• wherein the leaflet capture arm comprises a first arm segment forming a first loop and a second arm segment forming a second loop, and in a deployed state, the leaflet capture arm is resiliently biased toward an exterior surface of the support and configured to extend behind a native leaflet of the mitral valve to engage the native leaflet between the leaflet capture arm and the exterior surface of the support.

A heart valve repair device, comprising:

• a support structure having a first end portion and a second end portion with respect to a longitudinal axis of the support, wherein the support structure is configured to be positioned between native leaflets of a mitral valve;
• a supra-annular engagement segment comprising a plurality of interconnected struts extending laterally outwardly from the first end portion of the support and curving upwardly away from the support to an atraumatic end portion, wherein the supra-annular engagement segment has an outer tissue engagement surface configured to engage supra-annular tissue proximate to the mitral valve;
• and
• a leaflet capture arm extending radially outward from the second end portion of the support and configured to extend behind on of the native leaflet of the mitral valve in a deployed state, wherein the leaflet capture arm comprises a first arm segment forming a first loop and a second arm segment forming a second loop.

A method of repairing a native mitral valve of a patient, the method comprising:

• delivering a support of a heart valve repair device to a position between a posterior leaflet and an anterior leaflet of the native mitral valve, wherein the support comprises multiple interconnected struts, a first end portion, and a second end portion, and wherein the first end portion is positioned proximate to a left atrium and the second end portion is positioned proximate to the left ventricle;
• expanding a supra-annular engagement segment of the heart valve repair device within the left atrium such that an outer tissue engagement surface presses against and engages supra-annular tissue within the left atrium, wherein the supra-annular engagement segment extends laterally outwardly from the first end portion of the support and comprises multiple interconnected struts that form at least a portion of the outer tissue engagement surface;
• and
• extending a leaflet capture arm extending from the second end portion of the support behind the native posterior leaflet, wherein the leaflet capture arm comprises a first arm segment forming a first loop and a second arm segment forming a second loop.