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US 2021/0063394 A1Published application
Methods and compositions for diagnosis of rickettsia infection
AssigneeBoard of Regents, The University of Texas System
InventorsAllan R. BRASIER, Yingxin ZHAO, David H. WALKER, Rong FANG
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Abstract
Certain embodiments are directed to detection methods and methods of identifying detection targets for sensitive and specific laboratory tests to diagnose and monitor rickettsial infections during the earliest stages of the disease and to assess the degree of illness.
Claims8
A method for detecting and treating acute phase rickettsia infection comprising:
- contacting a sample from a subject with antibodies that bind rickettsial protein RC0497 (SEQ ID NO:1) or peptides thereof, wherein one or more antibodies form an antibody complex with RC0497 peptides in the sample;
- isolating the antibody;
- detecting the peptides present in the antibody complex;
- and
- treating the subject identified as having an acute phase rickettsia infection.
2 more elements
A polyclonal antibody composition that specifically binds rickettsial protein RC0497 (SEQ ID NO:1).
Dependencies are inferred from the claim text.