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US 2021/0063382 A1Published application
Method and system for screening anti-tumour substances
OwnerJinyu ZHANGinventor
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Abstract
Provided is a system for screening anti-tumour substances. The system comprises a first expression vector which encodes a first regulatory factor and a second expression vector which encodes a biological macromolecule, and the expression of the biological macromolecule can be co-regulated by the first regulatory factor and an inducer. Also provided are a method for preparing the system, a method for screening anti-tumor substances by using the system and anti-tumour substances obtained by screening.
Claims14
A system for screening anti-tumor substances, comprising:
- 1) a first expression vector encoding a first regulatory factor;
- and
- 2) a second expression vector encoding a biological macromolecule, wherein an expression of the biological macromolecule can be co-regulated by the first regulatory factor expressed by the first expression vector and an inducer, and the biological macromolecule is a candidate anti-tumor substance to be screened.
A method for screening anti-tumor substances, comprising:
- 1) providing a cell comprising a first expression vector encoding a first regulatory factor and a second expression vector encoding a biological macromolecule, wherein an expression of the biological macromolecule can be co-regulated by the first regulatory factor expressed by the first expression vector and an inducer;
- 2) administering the inducer, so that the inducer and the first regulatory factor co-activate the expression of the biological macromolecule encoded by the second expression vector;
- and
- 3) detecting the effect of the expression of the biological macromolecule on the growth and/or survival of the tumor, wherein the biological macromolecule is a candidate anti-tumor substance to be screened.
1 more element
Dependencies are inferred from the claim text.