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AssigneeNano Hesgarsazan Salamat Arya Ncubation Center for Medical Equipment and Devices
InventorsMohammad Abdolahad, Ali Saeidi
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An electromechanical system for detecting cancerous state of a single cell. The electromechanical system includes an aspirating mechanism, an electrical measurement mechanism, and a processing mechanism. The aspirating mechanism is configured to extract a single cell from a suspension of a plurality of suspended biological cells, hold the extracted single cell, and apply a mechanical aspiration to the held single cell by applying a suction force to the held single cell. The electrical measurement mechanism is configured to apply a set of electrical signals to the single cell before and after applying the mechanical aspiration, measure a first set of electrical responses from the held single cell corresponding to the applied set of electrical signals before the mechanical aspiration, and measure a second set of electrical responses from the mechanically aspirated single cell corresponding to the applied set of electrical signals before the mechanical aspiration. The processing mechanism, including a data processor, configured to detect cancerous state of the single cell based on a difference between the first set of electrical responses and the second set of electrical responses.
1- An electromechanical system for detecting cancerous state of a single cell, comprising:
2- The electromechanical system of claim 1, wherein the set of electrical signals comprises a set of electrical voltages of 40 mV at a set of frequency values in a range between 100 Hz and 100 KHz.
3- The electromechanical system of claim 1, wherein each of the first set of electrical responses and the second set of electrical responses comprise a set of at least one of electrical impedance values, electrical phase values, and combinations thereof.
4- The electromechanical system of claim 3, wherein the data processor is configured to:
5- The electromechanical system of claim 1, wherein the aspirating mechanism comprises:
6- The electromechanical system of claim 5, wherein the electrically activated micropipette comprises:
7- The electromechanical system of claim 6, wherein the micropipette is made of at least one of glass, quartz, plastic, and combinations thereof.
8- The electromechanical system of claim 5, wherein:
9- The electromechanical system of claim 1, wherein the electrical measurement mechanism comprises:
10- The electromechanical system of claim 9, wherein the electrical probe comprises:
11- The electromechanical system of claim 10, wherein the catalyst layer comprises a catalyst bilayer comprising a nickel layer over a gold layer.
12- The electromechanical system of claim 11, wherein the catalyst layer comprises the nickel layer with a thickness in a range between 10 nm and 40 nm over the gold layer with a thickness in a range between 1 nm and 4 nm.
13- The electromechanical system of claim 10, wherein the gold layer coated over the plurality of doped SiNTs has a thickness of 5 nm or less.
14- The electromechanical system of claim 10, wherein the plurality of doped SiNTs comprises a plurality of doped SiNTs with phosphorus.
15- The electromechanical system of claim 9, wherein the electrical probe is assembled on a microinjection microscope.
16- The electromechanical system of claim 9, wherein the signal controlling system comprises:
17- The signal controlling system of claim 16, wherein the AC signal source is configured to apply a voltage of 40 mV in a frequency range between 100 Hz and 100 KHz to the electrical probe.
18- The electromechanical system of claim 1, wherein the biological cells comprise a plurality of cells with elastic cell membranes, the cells comprising at least one of epithelial cells, endothelial cells, mesenchymal cells, and combinations thereof.