Molecular subtyping of small cell lung cancer to predict therapeutic responses
AssigneeBoard of Regents, The University of Texas System
InventorsCarl M. GAY, Lauren A. BYERS, John V. HEYMACH
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Abstract
Provided herein are methods for determining a subtype of a small cell lung cancer in a patient based on the express status of ASCL1, NEUROD1, and POU2F3, which are expressed in a mutually exclusive fashion. The subtype of the cancer can be used to determine the sensitivity of the cancer to certain anti-cancer therapies. As such, also provided are methods of treating patients having small cell lung cancer based on the subtyping results.
Claims25
A method of classifying a patient having a small cell lung cancer, the method comprising:
- (a) obtaining a sample of the patient's cancer;
- (b) measuring an expression level of ASCL1, NEUROD1, and POU2F3 in the sample or determining a methylation status of ASCL1, NEUROD1, and POU2F3 in the sample;
- and
- (c) classifying the patient having a small cell lung cancer based on the expression level of ASCL1, NEUROD1, and POU2F3 in the sample or the methylation status of ASCL1, NEUROD1, and POU2F3 in the sample.
14-15. (canceled)
18-27. (canceled)
31-33. (canceled)
A method of treating a patient having a small cell lung cancer, the method comprising administering a therapeutically effective amount of a PARP inhibitor, a nucleoside analogue, an anti-metabolite, or a platinum-containing chemotherapeutic agent to the patient, wherein the patient's cancer expresses POU2F3 or wherein the POU2F3 gene in the patient's cancer is not methylated.
35-57. (canceled)
A method of treating a patient having a small cell lung cancer, the method comprising administering a therapeutically effective amount of an immune checkpoint inhibitor or a BTK inhibitor to the patient, wherein the patient's cancer has been determined to expresses none of ASCL1, NEUROD1, and POU2F3 or wherein it has been determined that each of ASCL1, NEUROD1, and POU2F3 is methylated in the patient's cancer.
59-78. (canceled)
Dependencies are inferred from the claim text.