Method for producing chiral amines
AssigneeVito NV
InventorsYamini SATYAWALI, Dominic ORMEROD, Claudia MATASSA, Karolien VANBROEKHOVEN
Life of this patent
Estimating the term…
Abstract
A method for producing a chiral amine may include performing a transamination reaction of a prochiral amino acceptor and an amino donor in a first solution in the presence of a transaminase, thereby forming a chiral amine and a co-product in the first solution. The amino donor is a high molecular weight (HMW) amino donor. In some examples, the molecular weight of the HMW amino donor is at least 150 g/mol. In some examples, the amino donor is affixed on a support, the total molecular weight of the amino donor and the support being at least 150 g/mol.
Claims18
A method for producing a chiral amine, the method comprising:
- forming a chiral amine and a co-product in a first solution by performing a transamination reaction of a prochiral amino acceptor and an amino donor in the first solution in the presence of a transaminase;
- wherein the amino donor is a high molecular weight (HMW) amino donor, and wherein (a) a molecular weight of the high molecular weight amino donor being is at least 200 g/mol, or (b) the amino donor is affixed on a support, a total molecular weight of the amino donor and the support being at least 200 g/mol;
- and
- separating the chiral amine from the first solution by means using a porous membrane.
A method for producing a chiral amine, the method comprising the steps of:
- forming a chiral amine and a co-product in a first solution by performing a transamination reaction of a prochiral amino acceptor and an amino donor in the first solution in the presence of a transaminase;
- wherein the amino donor is a high molecular weight amino donor, and wherein the high molecular weight amino donor is poly(ethylene glycol) bis (3-aminopropyl), 1,4-bis(3-aminopropyl)piperazine, poly(propylene glycol) bis(2-aminopropyl ether), O-(2-Aminopropyl)-O′-(2-methoxyethyl)polypropylene glycol, O,O′-Bis(2-aminopropyl) polypropylene glycol-block-polyethylene glycol-block-polypropylene glycol, or 1,2-bis(3-aminopropylamino)ethane;
- and
- separating the chiral amine from the first solution using a porous membrane.
A method for producing a chiral amine, the method comprising:
- forming a chiral amine and a co-product in a first solution by performing a transamination reaction of a prochiral amino acceptor and an amino donor in the first solution in the presence of a transaminase, wherein the amino donor has a molecular weight of at least 200 g/mol;
- and
- separating the chiral amine from the first solution using a porous membrane.
Dependencies are inferred from the claim text.