Plasmid constructs for heterologous protein expression and methods of use
AssigneeOncoSec Medical Incorporated
InventorsJean Campbell, David A. Canton, Robert H. Pierce
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Abstract
Provided are plasmid vector constructs encoding multiple immunomodulatory proteins where each protein or component thereof can be expressed utilizing appropriate promoters and/or translation modifiers. Additional immunomodulatory proteins and genetic adjuvants containing shared tumor antigens can be added to further therapeutic potential as well as allow tracking of therapeutic treatment. Also provides are methods of expressing the plasmid constructs.
Claims18
A method of reducing cancer growth in a lung in a subject comprising injecting at least one pharmaceutically effective dose of at least one nucleic acid encoding IL-12 into a tumor in the subject and administering at least one electroporation pulse to the tumor.
Dependencies are inferred from the claim text.