Intracellular delivery of target-silencing protein
OwnerJoel NORDIN, Justin HEAN +1inventors
InventorsJoel NORDIN, Justin HEAN, Per LUNDIN
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Abstract
The present invention relates to extracellular vesicle (EV)-mediated delivery of protein-based therapeutics. More specifically, the invention relates to delivery of complex polypeptide-based agents which typically bind to target proteins extracellularly, intracellularly, or in the cell membrane.
Claims22
A genetically engineered extracellular vesicle (EV) comprising a TRIM ligase or a domain or region thereof.
A method for degrading a target protein, comprising the steps of (i) allowing an antibody to bind its antigen and (ii) delivering a ubiquitin ligase into proximity of the antibody with the aid of an EV.
A polypeptide construct comprising an exosomal protein and a TRIM21 ligase.
Dependencies are inferred from the claim text.