Complement factor h antibodies

An isolated antibody or antibody fragment thereof which immunospecifically binds to Complement Factor H (CFH) protein, wherein the antibody comprises:

• i. a variable heavy domain chain comprising a CDR1 comprising the amino acid sequence of SEQ ID NO:11, a CDR2 comprising the amino acid sequence of SEQ ID NO:21, and a CDR comprising the amino acid sequence of SEQ ID NO:31, and a variable light domain chain comprising a CDR1 comprising the amino acid sequence of SEQ ID NO:51, a CDR2 comprising the amino acid sequence of SEQ ID NO:61, and a CDR3 comprising the amino acid sequence of SEQ ID NO:71;
• ii. a variable heavy domain chain comprising a CDR1 comprising the amino acid sequence of SEQ ID NO:12, a CDR2 comprising the amino acid sequence of SEQ ID NO:22, and a CDR comprising the amino acid sequence of SEQ ID NO:32, and a variable light domain chain comprising a CDR1 comprising the amino acid sequence of SEQ ID NO:52, a CDR2 comprising the amino acid sequence of SEQ ID NO:62, and a CDR3 comprising the amino acid sequence of SEQ ID NO:72;
• iii. a variable heavy domain chain comprising a CDR1 comprising the amino acid sequence of SEQ ID NO:13, a CDR2 comprising the amino acid sequence of SEQ ID NO:23, and a CDR comprising the amino acid sequence of SEQ ID NO:33, and a variable light domain chain comprising a CDR1 comprising the amino acid sequence of SEQ ID NO:53, a CDR2 comprising the amino acid sequence of SEQ ID NO:63, and a CDR3 comprising the amino acid sequence of SEQ ID NO:73;
• iv. a variable heavy domain chain comprising a CDR1 comprising the amino acid sequence of SEQ ID NO:14, a CDR2 comprising the amino acid sequence of SEQ ID NO:24, and a CDR comprising the amino acid sequence of SEQ ID NO:34, and a variable light domain chain comprising a CDR1 comprising the amino acid sequence of SEQ ID NO:54, a CDR2 comprising the amino acid sequence of SEQ ID NO:64, and a CDR3 comprising the amino acid sequence of SEQ ID NO:74;
• v. a variable heavy domain chain comprising a CDR1 comprising the amino acid sequence of SEQ ID NO:15, a CDR2 comprising the amino acid sequence of SEQ ID NO:25, and a CDR comprising the amino acid sequence of SEQ ID NO:35, and a variable light domain chain comprising a CDR1 comprising the amino acid sequence of SEQ ID NO:55, a CDR2 comprising the amino acid sequence of SEQ ID NO:65, and a CDR3 comprising the amino acid sequence of SEQ ID NO:75;
• vi. a variable heavy domain chain comprising a CDR1 comprising the amino acid sequence of SEQ ID NO:16, a CDR2 comprising the amino acid sequence of SEQ ID NO:26, and a CDR comprising the amino acid sequence of SEQ ID NO:36, and a variable light domain chain comprising a CDR1 comprising the amino acid sequence of SEQ ID NO:56, a CDR2 comprising the amino acid sequence of SEQ ID NO:66, and a CDR3 comprising the amino acid sequence of SEQ ID NO:76;
• vii. a variable heavy domain chain comprising a CDR1 comprising the amino acid sequence of SEQ ID NO:17, a CDR2 comprising the amino acid sequence of SEQ ID NO:27, and a CDR comprising the amino acid sequence of SEQ ID NO:37, and a variable light domain chain comprising a CDR1 comprising the amino acid sequence of SEQ ID NO:57, a CDR2 comprising the amino acid sequence of SEQ ID NO:67, and a CDR3 comprising the amino acid sequence of SEQ ID NO:77;
• viii. a variable heavy domain chain comprising a CDR1 comprising the amino acid sequence of SEQ ID NO:18, a CDR2 comprising the amino acid sequence of SEQ ID NO:28, and a CDR comprising the amino acid sequence of SEQ ID NO:38, and a variable light domain chain comprising a CDR1 comprising the amino acid sequence of SEQ ID NO:58, a CDR2 comprising the amino acid sequence of SEQ ID NO:68, and a CDR3 comprising the amino acid sequence of SEQ ID NO:78;
• ix. a variable heavy domain chain comprising a CDR1 comprising the amino acid sequence of SEQ ID NO:19, a CDR2 comprising the amino acid sequence of SEQ ID NO:29, and a CDR comprising the amino acid sequence of SEQ ID NO:39, and a variable light domain chain comprising a CDR1 comprising the amino acid sequence of SEQ ID NO:59, a CDR2 comprising the amino acid sequence of SEQ ID NO:69, and a CDR3 comprising the amino acid sequence of SEQ ID NO:79;
• or
• x. a variable heavy domain chain comprising a CDR1 comprising the amino acid sequence of SEQ ID NO:20, a CDR2 comprising the amino acid sequence of SEQ ID NO:30, and a CDR comprising the amino acid sequence of SEQ ID NO:
• 40, and a variable light domain chain comprising a CDR1 comprising the amino acid sequence of SEQ ID NO:60, a CDR2 comprising the amino acid sequence of SEQ ID NO:70, and a CDR3 comprising the amino acid sequence of SEQ ID NO:80.