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US 2021/0061801 A1Published application
Dihydropyrimidinylthiazole for the treatment and prophylaxis of hepatitis b virus infection
AssigneeHoffmann-La Roche Inc.
InventorsXingchun HAN, Min JIANG, Yongguang WANG, Song YANG
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Abstract
The present invention provides novel compounds having the general formula: wherein R1, R2, X, Y and A are as described herein, compositions including the compounds and methods of using the compounds.
Claims18
A compound of the formula (I),
- wherein
- R1 is phenyl, which is unsubstituted or substituted one or two or three times by halogen or C1-6alkyl;
- R2 is C1-6alkyl;
- X is —(Cy)0-1-(L1)0-1-(L2)0-1-;
- wherein
- Cy is 3-20 membered heterocyclyl;
- L1 is C1-6alkyl or carboxyC1-6alkyl;
- L2 is O, S, —N(R3)— or —C(O)—NH—;
- wherein R3 is H or C1-6alkyl;
- Y is a bond, C1-9alkyl, C1-6alkoxyC1-6alkoxyC1-6alkyl or carboxyC1-9alkyl;
- A is formula (A1)
- wherein
- R4 is hydrogen or C1-6alkyl;
- R5 is hydrogen or C1-6alkoxy;
- or formula (A2)
- wherein
- R6 is hydrogen or halogen;
- R7 is hydrogen or halogen;
- R8 is hydrogen or C1-6alkyl;
- U is a bond or O;
- W is CH or N,
- or a pharmaceutically acceptable salt thereof.
19 more elements
Dependencies are inferred from the claim text.