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US 2021/0061748 A1Published application
Recombinant host cells and methods for the production of glyceric acid and downstream products
AssigneeLygos, Inc.
InventorsJeffrey A. Dietrich, Mario Ouellet, Johan van Walsem
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Abstract
Methods and materials related to producing glyceric acid and downstream products are disclosed. Specifically, isolated nucleic acids, polypeptides, host cells, methods and materials for producing glycolic acid by direct fermentation from sugars are disclosed.
Claims46
A recombinant host cell, comprising:
- a glyceric acid biosynthetic pathway, comprising heterologous nucleic acids encoding a 3-phosphoglycerate phosphatase and a 2-phosphoglycerate phosphatase;
- wherein the expression of the heterologous nucleic acids produces glyceric acid.
A method for producing glycerate esters, comprising:
- recovering glyceric acid and glycerate salts from a cell-containing fermentation broth;
- reacting the glyceric acid and glycerate salts with an alcohol in the presence of sulfuric acid to produce a glycerate ester;
- and
- isolating the glycerate ester by distillation.
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A method for producing acrylate esters, comprising:
- reacting a glycerate ester with a reducing agent in the presence of a transition metal catalyst to produce an acrylate ester;
- and
- isolating the acrylate ester;
- wherein the transition metal catalyst is selected from vanadium compounds, molybdenum compounds, and rhenium compounds.
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A poly(glycerate carbonate) compound comprising repeat units of formula (I):
- —[O CH(C(═O)OR1)CH2OC(═O)]—
- or a salt thereof;
- wherein
- each R1 is independently selected from hydrogen, optionally substituted C1-C5 alkyl, and optionally substituted aryl.
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Dependencies are inferred from the claim text.