Compositions and devices for removal of endotoxins and cytokines from fluids
AssigneeThe Research Foundation for The State University of New York
InventorsJuntao LUO, Lili WANG, Changying SHI
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Abstract
Provided are sorption materials and devices using the sorption materials, and methods of using the sorption materials and devices containing the sorption materials. In various examples, the sorption materials bind to various inflammation stimulating and/or mediating molecules, which are often associated with systemic infections and systemic inflammation associated with conditions such as, for example, sepsis.
Claims14
A method for treating a subject having or suspected of having a systemic infection and/or systemic inflammation comprising:
- contacting a biological fluid from the subject with at least one sorption material,
- wherein the at least one sorption material comprises at least one compound bound to a substrate, wherein the compound has the following structure:
- R1-L1-D-(L2-R2)x,y
- wherein R1 is a bond or group attaching L1 or D to the substrate;
- L1 and L2 independently at each occurrence are optional and are linker groups;
- D is a dendritic polymer moiety having one or more branched monomer units (X), and a plurality of end groups;
- R2 independently at each occurrence is an end group of the dendritic polymer;
- x is the number of R2 end groups that are charged moieties and range from 1-32;
- and
- y is the number of R2 end groups that are each independently a lipophilic moiety or a hydrophobic moiety and range from 1-32, and
- wherein at least a portion of or all of the one or more of or all of inflammation stimulating and/or mediating molecules bind to the sorption material.
A device for removing inflammation stimulating and/or mediating molecules from a fluid comprising:
- a housing defining an inlet and an outlet, wherein the inlet and the outlet are in fluid communication with one another, and the housing is configured such that the fluid enters the housing through the inlet and exits the housing through the outlet;
- and
- a sorption material is disposed in the housing, wherein the sorption material comprises at least one compound bound to a substrate, wherein the compound has the following structure:
- R1-L1-D-(L2-R2)x,y
- wherein R1 is a bond or group attaching L1 or D to the substrate;
- L1 and L2 independently at each occurrence are optional and are linker groups;
- D is a dendritic polymer moiety having one or more branched monomer units (X), and a plurality of end groups;
- R2 independently at each occurrence is an end group of the dendritic polymer;
- x is the number of R2 end groups that are charged moieties and range from 1-32;
- and
- y is the number of R2 end groups that are each independently a lipophilic moiety or a hydrophobic moiety and range from 1-32.
A sorption material comprising at least one compound bound to a substrate, wherein the compound has the following structure:
- R1-L1-D-(L2-R2)x,y
- wherein R1 is a bond or group attaching L1 or D to the substrate;
- L1 and L2 independently at each occurrence are optional and are linker groups;
- D is a dendritic polymer moiety having one or more branched monomer units (X), and a plurality of end groups;
- R2 independently at each occurrence is an end group of the dendritic polymer;
- x is the number of R2 end groups that are charged moieties and range from 1-32;
- and
- y is the number of R2 end groups that are each independently a lipophilic moiety or a hydrophobic moiety and range from 1-32.
Dependencies are inferred from the claim text.