Methods and compositions for deuterated biologics
AssigneeBristol-Myers Squibb Company
InventorsMichael J. SMITH, Haiying Tang, Paul E Morin, Harold J. Malone, Luciano MUELLER
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Abstract
Deuterated polymer-biomolecule conjugates and the synthesis and use of deuterated polymer-biomolecule conjugates for detecting the location of specific molecules, e.g., cell surface molecules, in a subject, and for imaging various processes within the body, for detecting the location of molecules associated with disease pathology, and for monitoring disease progression are disclosed.
Claims7
A method of obtaining an image of a D-polymer-biomolecule conjugate in a subject, the method comprising,
- (a) administering the D-polymer-biomolecule conjugate to the subject;
- and
- (b) imaging in vivo the distribution of the D-polymer-biomolecule conjugate by magnetic resonance imaging (MRI).
A method of diagnosing the presence of a disease in a subject, the method comprising
- (a) administering to a subject in need thereof a D-polymer-biomolecule conjugate, which conjugate binds to a target molecule associated with the presence of the disease;
- and
- (b) obtaining a magnetic resonance image of at least a portion of the subject to detect the presence or absence of the D-polymer-biomolecule conjugate;
- wherein the presence and location of the D-polymer-biomolecule conjugate above background is indicative of the presence and location of the disease.
A method of monitoring the progress of a disease in a subject, the method comprising
- (a) administering to the subject a D-polymer-biomolecule conjugate, which conjugate binds to a target molecule associated with the presence of the disease at a first time point and obtaining an image of at least a portion of the subject to determine the amount of the diseased cells or tissue;
- and
- (b) administering to the subject the D-polymer-biomolecule conjugate at one or more subsequent time points and obtaining an image of at least a portion of the subject at each time point,
- wherein the dimension and location of the diseased cells or tissue at each time point is indicative of the progress of the disease.
A method of determining the distribution of a deuterated molecule in a subject, the method comprising
- (a) orally administering the deuterated molecule to the subject and
- (b) imaging in vivo the distribution of the deuterated molecule by magnetic resonance imaging (MRI).
Dependencies are inferred from the claim text.