Methods of immunostimulation with complexes of rna and cationic carriers
AssigneeCureVac AG
InventorsMariola FOTIN-MLECZEK, Patrick BAUMHOF
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Abstract
The present invention relates to a complexed RNA, comprising at least one RNA complexed with one or more oligopeptides, wherein the oligopeptide has a length of 8 to 15 amino acids and has the empirical formula (Arg)l;(;Lys)m;(His)n;(Orn)o;(Xaa)x. The invention further relates to a method for transfecting a cell or an organism, thereby applying the inventive complexed RNA. Additionally, pharmaceutical compositions and kits comprising the inventive complexed RNA, as well as the use of the inventive complexed RNA for transfecting a cell, tissue or an organism and/or for modulating, preferably inducing or enhancing, an immune response are disclosed herein.
Claims25
A method of stimulating an immune response in a subject comprising administering an effective amount of a pharmaceutical composition comprising a purified mRNA encoding a coronavirus antigen to the subject, wherein said mRNA is complexed or formulated with a cationic carrier molecule.
Dependencies are inferred from the claim text.