Light-Controlled Antibacterial Agent Composed of Linear Cationic Oligopeptide and Multi-arm B-Cyclodextrin

A light-controlled antibacterial agent composed of linear cationic oligopeptide and multi-arm β-cyclodextrin, characterized by being prepared by the following method:

• respectively dissolving linear cationic oligopeptide and multi-arm β-cyclodextrin host molecules in redistilled water to obtain clear and transparent solutions, controlling the ratio of the mole number of azobenzene in the linear cationic oligopeptide to the mole number of β-cyclodextrin in the multi-arm β-cyclodextrin host molecules to 1:1, adding the aqueous solution of the multi-arm cyclodextrin host molecules dropwise to the aqueous solution of the linear cationic oligopeptide under stirring at room temperature, and controlling the concentration of the linear cationic oligopeptide in the final solution to 75-300 μM and the pH value to 6.5-7.5;
• and then keeping the solution at 15-30° C. for 12-48 h, so the linear cationic oligopeptide and the multi-arm β-cyclodextrin host molecules are connected through “host-guest” recognition between β-cyclodextrin and azobenzene to form sheet-form cross-linked aggregates with micron-scale length and width, thus obtaining the aqueous solution of the light-controlled antibacterial agent composed of linear cationic oligopeptide and multi-arm β-cyclodextrin.