Inula helenium extracts for treating and preventing pollution related damage
OwnerFabien HAVAS, Leah VON OPPEN-BEZALEL +2inventors
InventorsFabien HAVAS, Leah VON OPPEN-BEZALEL, Olga BEN-CHITRIT, Inon PERRY
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Abstract
Extracts derived from plants and/or fractions thereof, compositions comprising same and methods and use thereof in protecting tissues from damage caused by toxins are encompassed herein. More particularly, compositions comprising a polar solvent extract and/or a fraction thereof derived from an Inula plant (e.g., Inula helenium) and methods and use thereof in protecting tissues comprising epithelial cells from adverse effects of toxins, particularly exogenous toxins originating from environmental pollution, are encompassed herein.
Claims29
1:
- A method for protecting a tissue comprising epithelial cells from adverse effects of at least one pollutant, the method comprising administering to a subject in need thereof at least one of:
- (a) a polar solvent extract derived from an Inula plant,
- (b) a fraction of the polar solvent extract derived from an Inula plant, or
- (c) a composition comprising the polar solvent extract derived from an Inula plant or the fraction of the polar solvent extract derived from an Inula plant,
- in an effective amount sufficient to protect the tissue comprising epithelial cells from adverse effects of the at least one pollutant, thereby protecting the tissue from the at least one pollutant.
2:
- The method of claim 1, wherein the administering is performed before, during, or after exposure to the at least one pollutant.
3-9. (canceled)
10:
- The method of claim 1, wherein the tissue is skin and wherein the method comprises topically administering at least one of the polar solvent extract, the fraction of the polar solvent, and the composition comprising the polar solvent extract or the fraction thereof to the skin.
11-22. (canceled)
23:
- The method of claim 1, wherein the polar solvent is water.
24:
- The method of claim 1, wherein the polar solvent comprises water and at least one additional polar solvent selected from the group of glycerin, ethanol, propylene glycol, butylene glycol, methanol and acetone.
(canceled)
26:
- The method of claim 24, wherein the polar solvent comprises water and glycerin.
27:
- The method of claim 1, wherein the polar solvent extract or the fraction of the polar solvent extract is essentially devoid of essential oils.
28:
- The method of claim 1, wherein the polar solvent extract or the fraction of the polar solvent extract is derived from the Inula plant, excluding roots of the Inula plant.
29:
- The method of claim 1, wherein the Inula plant is Inula helenium.
30:
- A composition comprising a polar solvent extract derived from an Inula plant or a fraction of the polar solvent extract derived from an Inula plant in:
- (a) an amount effective to protect a tissue comprising epithelial cells from adverse effects of at least one pollutant, or
- (b) an effective amount sufficient to at least partially restore tissue function,
- the composition optionally further comprising a cosmetically, pharmaceutically, or dermatologically acceptable diluent, excipient or carrier.
31:
- The composition according to claim 30, wherein the Inula plant is Inula helenium.
32:
- The composition according to claim 30, wherein the polar solvent extract or the fraction of the polar solvent extract is derived from the whole Inula plant or any aerial parts of the Inula plant.
33-34. (canceled)
35:
- The composition of claim 30, wherein the polar solvent is water.
36:
- The composition of claim 30, wherein the polar solvent comprises water and at least one additional polar solvent selected from the group of glycerin, ethanol, propylene glycol, butylene glycol, methanol and acetone.
(canceled)
38:
- The composition of claim 30, wherein the polar solvent extract or the fraction of the polar solvent extract comprises up to 1% w/w essential oils.
(canceled)
40:
- The composition of claim 30, further comprising at least one additional plant extract or at least one microalgae extract.
(canceled)
42:
- The composition of claim 30, further comprising an additional active agent comprising an anti-oxidant, a chelator, a cleansing agent, a skin protectant, a sunscreen, a skin lightening agent, an anti-wrinkling agent, an anti-inflammatory agent, an anti-aging agent, or any combination thereof.
43-58. (canceled)
59:
- A polar solvent extract derived from an Inula plant/or a fraction of the polar solvent extract or a composition comprising a polar solvent extract derived from an Inula plant/or a fraction of the polar solvent extract for use in protecting a tissue comprising epithelial cells from adverse effects of at least one pollutant or at least partially restoring tissue function of a tissue comprising epithelial cells damaged by exposure to adverse effects of at least one pollutant.
60:
- The polar solvent extract of claim 59, wherein the Inula plant is Inula helenium.
61:
- The polar solvent extract of claim 59, wherein the polar solvent extract or the fraction of the polar solvent extract is derived from the Inula plant, excluding roots of the Inula plant.
62-64. (canceled)
Dependencies are inferred from the claim text.