Topical administration of mek inhibiting agents for the treatment of skin disorders
AssigneeDuke University
InventorsYunyan ZHANG, Adela Rambi G. CARDONES, Yingai JIN, Simone DEGAN, Russell HALL
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Abstract
The instant disclosure provides methods and compositions related to discovery that topical administration of MEK inhibitors for the treatment of skin disorders (e.g., skin cancer, inflammatory skin disorders) is accomplished with markedly reduced dosage levels in comparison with oral administration dosage levels. Therapeutic and/or prophylactic uses and compositions of known MEK inhibitors are described.
Claims24
A method of treating or preventing a skin disorder in a patient in need thereof, the method comprising topical administration of a pharmaceutical composition to the area in need of treatment,
- wherein the pharmaceutical composition comprises a therapeutically effective amount of a MEK inhibiting agent and a pharmaceutically acceptable diluent or carrier,
- wherein the pharmaceutical composition is in a form selected from ointments, gels, creams, lotions, oil-in-water emulsions, water-in-oil emulsions, microemulsions, foams, sprays, mousses, patches, powders, pastes, and medicated plasters.
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Dependencies are inferred from the claim text.