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AssigneesKyoto University, Kyoto Prefectural Public University Corporation, The Doshisha
InventorsHanako Ikeda, Akira Kakizuka, Shigeru Kinoshita, Takahiro Nakamura, Maho Nagata, Noriko Koizumi, Naoki Okumura
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The inventors have found that VCP inhibitors protect corneal endothelial cells and corneal epithelial cells. Accordingly, the disclosure provides a composition for protecting a cornea comprising a compound of formula (I) or an ester, oxide, pharmaceutically acceptable salt or solvate thereof. In another aspect the disclosure provides a composition for treating and/or preventing a corneal disease comprising a compound of formula (I). In a further aspect the disclosure provides a composition for ocular irrigation comprising a compound of formula (I). In a still further aspect the disclosure provides a composition for preserving a corneal graft comprising a compound of formula (I).
A method of treating or preventing a corneal disease in a subject in need thereof, comprising administering a compound of formula (I):
(canceled)
11-13. (canceled)
A composition, comprising a compound of formula (I):
A composition comprising a compound of formula (I):
Dependencies are inferred from the claim text.