Heteroaromatic compounds as vanin inhibitors

A compound of the formula I,

• or a pharmaceutically acceptable salt thereof, wherein
• n denotes 1, 2 or 3;
• m denotes 1, 2 or 3;
• R1 and R2 are independently from each other selected from the group consisting of H, C1-4-alkyl optionally substituted by 1-3 F-atoms or C1-2-alkoxy, 6-10 membered aryl substituted by R2.1 and 5-6 membered heteroaryl substituted by R2.1,
• wherein
• R2.1 is selected from the group consisting of H, F, Cl, Br, —CN, NR2.1.1R2.1.2, SO2R2.1.3 and OR2.1.4,
• wherein
• R2.1.1, R2.1.2 independently from each other denote H, C1-4-alkyl or C3-4-cycloalkyl;
• or
• R2.1.1 and R2.1.2 together with the N-atom to which they are attached form a 4-5 membered heterocyclyl or a 6 membered heterocyclyl optionally containing one additional heteroatom selected from the group consisting of N and O;
• R2.1.3 denotes C1-4-alkyl or NR2.1.1 R2.1.2,
• R2.1.4 is selected from the group consisting of H, C1-4-alkyl, C3-5-cycloalkyl, 4-5 membered heterocyclyl containg 1 heteroatom selected from the group consisting of N and O.
• wherein in the definition of R2.1.1, R2.1.2, R2.1.3 and R2.1.4 mentioned alkyl, cycloalkyl and heterocyclyl are optionally substituted by 1-3 F-atoms or one C1-2-alkoxy;
• or
• R1 and R2 together may form a 3-5 membered carbocycle or 4-6 membered heterocyclyl containg one heteroatom selected from the group consisting of N and O;
• R3 denotes NR3.1R3.2;
• or
• R3 denotes a group of formula R3.a or R3.b
• wherein
• X denotes CH2, NRX or O;
• wherein RX denotes H or C1-3-alkyl;
• R3.1 is selected from the group consisting of C1-4-alkyl-CO— optionally substituted by 1-3 F-atoms, C3-4-cycloalkyl or C1-2-alkoxy, R3.1.3R3.1.4N—CO—, R3.1.5O—CO—, pyrimidine, pyridine, C3-5-cycloalkyl-CO— substituted with R3.1.1 and R3.1.2, 4-6 membered heterocyclyl-CO— substituted with R3.1.1 and R3.1.2, phenyl-CO— substituted with R3.1.1 and R3.1.2;
• wherein
• R3.1.1, R3.1.2 independently from each other are selected from the group consisting of H, —CH3, —OR3.1.1.1, F and —CN;
• R3.1.3, R3.1.4 independently from each other denote H, C1-4-alkyl or C3-4-cycloalkyl;
• or
• R3.1.3 and R3.1.4 together with the N-atom to which they are attached form a form a 4-5 membered heterocyclyl or a 6 membered heterocyclyl optionally containing one additional heteroatom selected from the group consisting of N and O;
• R3.1.5 is selected from the group consisting of C1-4-alkyl, C3-5-cycloalkyl, 4-5 membered heterocyclyl and C3-4-cycloalkyl-CH2—;
• R3.1.1.1 denotes C1-4-alkyl, C3-5-cycloalkyl or 4-5 membered heterocyclyl;
• wherein in the definition of R3.1.1, R3.1.2, R3.1.3, R3.1.4, R3.1.5 and R3.1.1.1 mentioned alkyl, cycloalkyl and heterocyclyl are optionally substituted by 1-3 F-atoms or one C1-2-alkoxy;
• R3.2 is selected from the group consisting of H, C1-4-alkyl, C3-4-cycloalkyl, C3-4-cycloalkyl-C1-2-alkyl- and phenyl-C1-2-alkyl-;
• wherein in the definition of R3.2 mentioned alkyl, cycloalkyl and phenyl are optionally substituted by 1-3 F-atoms or one C1-2-alkoxy;
• R4 denotes hydrogen or C1-4-alkyl optionally substituted with 1 to 3 F-atoms;
• or
• R3 and R4 together form a 4-6-membered heterocycle containing one oxygen atom.