Methods and materials for identifying and treating cancer
AssigneeAmit K. Verma
InventorsNiraj K. Shenoy, Thomas E. Witzig, Amit K. Verma
Life of this patent
Estimating the term…
Abstract
This document provides methods and materials involved in identifying and treating mammals having a cancer (e.g., a clear cell renal cell carcinoma (ccRCC)) based, at least in part on, 5-hydroxymethylcytosine (5hmC) levels. For example, methods and materials for administering a high dose of ascorbic acid (AA) with or without an additional chemotherapeutic agent to a mammal identified as having cancer having a reduced level of 5hmC are provided. Methods and materials for administering a chemotherapeutic agent without administering a high dose of AA to a mammal identified as having cancer exhibiting 5hmC expression also are provided.
Claims25
1-8. (canceled)
A method for treating cancer, wherein said method comprises:
- (a) identifying a mammal as having a cancer comprising a reduced level of 5hmC, and
- (b) administering a high dose of AA, a chemotherapeutic agent, or a targeted therapy to said mammal.
12-14. (canceled)
24-29. (canceled)
A method for treating metastatic cancer or cancer in an unresectable setting, wherein said method comprises administering, to a mammal identified as having a cancer comprising a reduced level of 5hmC, a high dose of AA in combination with one or more chemotherapeutic agents or one or more targeted therapies.
34-39. (canceled)
A method for treating cancer in a localized setting, wherein said method comprises administering, to a mammal identified as having a cancer comprising a reduced level of 5hmC, a high dose of AA, one or more chemotherapeutic agents, or one or more targeted therapies.
44-53. (canceled)
Dependencies are inferred from the claim text.