Stimulation of t regulatory cells by cannabidiol as a means of treating arthritis and autoimmunity
AssigneeRegen Biopharma, Inc.
InventorsThomas Ichim, David Koos
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Abstract
Disclosed are means, methods, and compositions of matter for stimulation of T regulatory (Treg) cells by cannabidiol. In one embodiment, administration of cannabidiol is performed in an animal suffering from autoimmunity. In situations of autoimmunity, cannabidiol induces generation of Treg cells while other agents or therapies may be used to expand such cells in vitro and/or in vivo. In some embodiments the administration of cannabidiol is performed together with agents such as low dose interleukin-2 in order to treat inflammatory conditions such as arthritis or other conditions associated with reduction in Treg cells such as pregnancy failure, type 1 diabetes, or graft versus host disease.
Claims20
A method of inducing T regulatory cells in vivo comprising the steps of:
- a) providing cannabidiol to a mammal at a concentration sufficient to induce expression of Foxp3 in T cells possessing the marker CD4;
- and b) altering the dose of cannabidiol as needed in order to maintain an general increase in cells expressing CD4 and FoxP3.
Dependencies are inferred from the claim text.