Vapor Phase Coating Technology for Pharmaceutical Abuse Deterrent Formulations
AssigneeApplied Materials, Inc.
InventorColin C. Neikirk
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Abstract
A method of preparing an abuse deterrent pharmaceutical composition having a drug-containing core enclosed by one or more metal oxide materials is provided. The method includes the sequential steps of (a) loading the particles comprising the drug into a reactor, (b) applying a vaporous or gaseous metal precursor to the particles in the reactor, (c) performing one or more pump-purge cycles of the reactor using inert gas, (d) applying a vaporous or gaseous oxidant to the particles in the reactor, and (e) performing one or more pump-purge cycles of the reactor using inert gas. This produces an abuse deterrent pharmaceutical composition comprising a drug containing core enclosed by one or more metal oxide materials.
Claims29
A method of preparing an abuse deterrent pharmaceutical composition comprising a drug-containing core enclosed by a layer comprising one or more metal oxide materials, the method comprising the sequential steps of:
- (a) loading the particles comprising the drug into a reactor;
- (b) applying a vaporous or gaseous metal precursor to the particles in the reactor;
- (c) performing one or more pump-purge cycles of the reactor using inert gas;
- (d) applying a vaporous or gaseous oxidant to the particles in the reactor;
- and
- (e) performing one or more pump-purge cycles of the reactor using inert gas;
- wherein the, thereby producing an abuse deterrent pharmaceutical composition comprising a drug containing core enclosed by a layer comprising one or more metal oxide materials.
An abuse deterrent pharmaceutical composition comprising a drug-containing core enclosed by one or more metal oxide materials, the method comprising the sequential steps of:
- (a) loading particles comprising the drug into a reactor;
- (b) applying a vaporous or gaseous metal precursor to the particles in the reactor;
- (c) performing one or more pump-purge cycles of the reactor using inert gas;
- (d) applying a vaporous or gaseous oxidant to the particles in the reactor;
- and
- (e) performing one or more pump-purge cycles of the reactor using inert gas;
- thereby producing an abuse deterrent pharmaceutical composition comprising a drug containing core enclosed by one layer comprising a metal oxide materials.
Dependencies are inferred from the claim text.