Oral Drug Delivery System and Method for Fabricating Thereof
AssigneeNational Tsing Hua University
InventorsHsing-Wen Sung, Yang-Bao Miao, Kuan-Hung Chen
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Abstract
An oral drug delivery system includes a biomimetic mineralized carrier and a yeast capsule. The biomimetic mineralized carrier has a surface with positive charge and includes a metal organic framework having an internal space and a biological macromolecule encapsulated in the internal space of the metal organic framework. A surface of the metal organic framework has a plurality of pores. The yeast capsule is composed of a β-glucan cell-wall shell that removes a cytoplasm from yeast and has a surface with negative charge. The biomimetic mineralized carrier is loaded into the yeast capsule by an electrostatic force to form the oral drug delivery system.
Claims15
An oral drug delivery system, comprising:
- a biomimetic mineralized carrier having a surface with a positive charge, comprising:
- a metal organic framework having an internal space, wherein a surface of the metal organic framework has a plurality of pores;
- and
- a biological macromolecule encapsulated in the internal space of the metal organic framework;
- and
- a yeast capsule composed of a β-glucan cell-wall shell that removes a cytoplasm from a yeast, wherein the yeast capsule has a surface with a negative charge, and the biomimetic mineralized carrier is loaded into the yeast capsule by an electrostatic force.
Dependencies are inferred from the claim text.