Nanostructure Enhanced Targeting (NSET) of Inflammatory Cells
AssigneeNorthwestern University
InventorsEvan A. Scott, Sijia Yi, Sean D. Allen
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Abstract
The present invention provides nanomaterials for the specific targeting of immune cells. Methods of treating cardiac disease and inflammatory disease are also described.
Claims18
1-28. (canceled)
A method of treating cardiovascular disease comprising targeting a polymersome comprising block copolymers of poly(ethylene glycol) (PEG) and poly(propylene sulfide) (PPS) to a dendritic cell associated with cardiovascular disease in a subject, wherein the polymersome incorporates or encapsulates a therapeutic agent able to treat cardiovascular disease or a diagnostic.
A method of imaging a dendritic cell associated with an inflammatory response in a subject, the method comprising administering polymersomes comprising a diagnostic agent to the subject, wherein the diagnostic agent is an imaging agent, and wherein the polymersomes comprise a block copolymers of poly(ethylene glycol) (PEG) and poly(propylene sulfide) (PPS), and wherein the polymersomes are selectively taken up by dendritic cells.
Dependencies are inferred from the claim text.