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AssigneeCai Gu Huang
InventorsCai Gu Huang, Hailong Zhang, Abid Hussain
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The present invention is directed to a liposomal formulation having a lipid ingredient encapsulating fluticasone furoate, and a method for preparing the liposomal formulation. The liposome formulation comprises a lipid and a sterol. The method of preparing the liposomes comprises the steps of (1) mixing fluticasone furoate with lipid ingredients comprising a lipid and a sterol, (2) injecting the mixture into normal saline solution, and (3) ultrafiltering and concentrating the resulting solution. This preparation method can produce a liposome formulation having desirable properties and compositions, for example, the ratio of the lipid ingredient, the drug to lipid ratio, and the pH value, which is suitable for nebulization inhalation.
A formulation comprising a plurality of liposomes, wherein the liposomes comprise a lipid ingredient encapsulate fluticasone furoate, the lipid ingredient comprises a lipid and a sterol, and the molar ratio of lipid to sterol is from about 0.6:1 to about 1.4:1.
A method of preparing a formulation having a plurality of liposomes, comprising the steps of:
Dependencies are inferred from the claim text.