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US 2021/0059934 A1Published application
Methods and compositions for treating diabetic foot ulcers
AssigneePathway Development LLC
InventorsJEFFREY CLARK, JEFFERY KING
Life of this patent
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Abstract
In one aspect, the disclosure relates to methods and compositions, i.e., pharmaceutical formulations, for treating and preventing diabetic foot ulcers. In a particular aspect, the disclosed methods and compositions pertain to water-based pharmaceutical formulations that are useful for administration in an aqueous foot bath. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
Claims20
A pharmaceutical composition comprising:
- a first antimicrobial agent, a second antimicrobial agent, a third antimicrobial agent, and a powder excipient base;
- wherein the first antimicrobial agent is an aminoglycoside antibiotic or a fluoroquinolone, and is present in an amount of from about 15 wt % to about 35 wt %;
- wherein the second antimicrobial agent is glycopeptide antibiotic, and is present in an amount of from about 15 wt % to about 40 wt %;
- wherein the third antimicrobial agent is an azole antifungal or an imidazole antifungal, and is present in an amount of from about 1 wt % to about 15 wt %;
- wherein the powder excipient base is present in an amount of from about 10 wt % to about 50 wt %;
- wherein the wt % is based on the total weight of the first antimicrobial agent, the second antimicrobial agent, the third antimicrobial agent, and the powder excipient base such that the total wt % for foregoing components is 100 wt %;
- and
- wherein the first antimicrobial agent, the second antimicrobial agent, the third antimicrobial agent, and the powder excipient base are a homogeneously dispersed powder mixture.
5 more elements
Dependencies are inferred from the claim text.