Nanoparticulate mineralized collagen glycosaminoglycan scaffold with an anti-resorption factor
AssigneeThe Regents of the University of California
InventorsBrendan A. Harley, Justine C. Lee, Timothy A. Miller, Xiaoyan Ren
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Abstract
Compositions including a collagen glycosaminoglycan scaffold and osteoprotegerin are described. The compositions are useful in methods for promoting osteogenesis and attenuating bone resorption.
Claims27
A composition comprising a collagen glycosaminoglycan scaffold and one or more of an osteoprotegerin (OPG), an OPG fragment or an equivalent of each thereof.
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A method of preparing a composition, comprising contacting a MC-GAG scaffold with a solution comprising OPG, an OPG fragment or an equivalent of each thereof.
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A method of preparing a composition comprising:
- culturing in a differentiation medium a MSC expressing exogenous osteoprotegerin (OPG), an exogenous OPG fragment or an equivalent of each thereof;
- within a collagen glycosaminoglycan scaffold.
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Dependencies are inferred from the claim text.