Chitosan dressing for control of gastrointestinal bleeding
AssigneeTricol Biomedical, Inc.
InventorsCole GANNETT, Simon J. MCCARTHY, Ervelyn WINATA
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Abstract
The present invention relates to a biocompatible, foldable, thin profile, low mass and high surface area, chitosan dressing, optionally modified with catechol, and suitable for treating bleeding in a physiological environment, e.g. gastrointestinal tract. The characteristics and structures of the chitosan dressing are provided. Methods of making and using the chitosan dressing are also provided.
Claims64
A chitosan dressing comprising a catechol modified chitosan, wherein the dressing is hemostatic and has a thickness that is 500 microns or less.
A method of producing a catechol modified chitosan dressing, comprising:
- (a) performing synthesis with chitosan and catechol in an aqueous reaction solution;
- (b) maintaining a pH of the reaction solution at or below pH 5.5;
- (c) after step (b), increasing the pH of the reaction solution, and controlling oxygen exposure to the reaction solution, to provide catechol oxidation and cross-linking;
- and
- (d) drying the reaction solution;
- wherein the method does not comprise an intermediate drying step between step (b) and step (c).
A method of producing a chitosan dressing comprising:
- (a) freeze-drying a first aqueous solution comprising chitosan;
- (b) freeze-drying a second aqueous solution comprising chitosan;
- (c) obtaining a low-density chitosan dressing with inter-connected porous structure from each of steps (a) and (b);
- and
- (d) compressing the low-density chitosan dressing from each of steps (a) and (b);
- and
- (e) preparing a two-layer chitosan dressing from the compressed low-density chitosan dressing from each of steps (a) and (b).
Dependencies are inferred from the claim text.