Neural stem cell compositions including chimeric poxviruses for cancer treatment
AssigneeCity of Hope
InventorsAlexandra J. ANNALA, Karen S. ABOODY, Yuman FONG, Nanhai G. CHEN, Mohamed HAMMAD, Rachael MOONEY, Jennifer COVELLO
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Abstract
Provided are methods and compositions for treating cancer with a combination of neural stem cells (NSCs) and a replication-competent oncolytic virus such as conditionally replication-competent chimeric orthopoxvirus (CF33). The cancer includes but is not limited to primary, recurrent, and metastatic brain cancer, breast cancer, head and neck cancer, bladder cancer, ovarian cancer, uterine cancer, prostate cancer, skin cancer, lung cancer, and colorectal cancer.
Claims49
A method of treating cancer, said method comprising administering to a subject in need thereof an effective amount of a chimeric poxvirus and a neural stem cell (NSC).
A composition comprising a chimeric poxvirus and a neural stem cell (NSC).
A neural stem cell (NSC) comprising a chimeric poxvirus.
Dependencies are inferred from the claim text.