Plasmonic biosensor
AssigneeEcole Polytechnique Federale De Lausanne (Epfl)
InventorsAlexander BELUSHKIN, Filiz YESILKÖY, Hatice Yanik ALTUG
Life of this patent
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Abstract
The present invention relates to a plasmonic biosensor system. The system includes a nano-hole array device comprising at least one nano-hole array (NHA) including at least one or a plurality of nano holes (NH), an image sensor (A3) for capturing light provided by a light source (A1) and transmitted through the nano-hole array (NHA), and at least one or a plurality of nano-particles (NP) configured to be received by the nano-holes (NH) of the nano-hole array (NHA).
Claims21
-57. (canceled)
Plasmonic biosensor system including:
- a nano-hole array device comprising at least one nano-hole array including a plurality of nano holes, the at least one nano-hole array being able to be functionalized to capture a target antigen or biomarker,
- an image sensor for capturing light provided by a light source for illuminating the nano-hole array and transmitted through the nano-hole array, and
- at least one or a plurality of nano-particles configured to be received by the nano-holes of the nano-hole array, the at least one or the plurality of nano-particles comprising or consisting solely of at least one metal and the at least one or the plurality of nano-particles being able to be functionalized with at least one molecule configured to bind or conjugate to a target antigen or biomarker
- wherein the system further includes calculation means or a processor configured to receive image data from the image sensor and configured to determine or count the nano-holes on the nano-hole array at which a suppression or reduction of transmission intensity occurs using the received image data.
Plasmonic bio-sensing method including the steps of:
- providing a nano-hole array device comprising at least one nano-hole array including a plurality of nano holes,
- providing a light source for illuminating the nano-hole array,
- providing an image sensor for capturing light provided by the light source and transmitted through the nano-hole array, and
- providing at least one or a plurality of nano-particles configured to be received by the nano-holes of the nano-hole array, the at least one or the plurality of nano-particles comprising or consisting solely of at least one metal;
- and
- functionalizing the at least one nano-hole array to capture a target antigen or biomarker, and functionalizing the at least one or the plurality of nano-particles with at least one molecule configured to bind or conjugate to the target antigen or biomarker;
- wherein the method further includes the step of determining or counting the nano-holes on the nano-hole array at which a suppression or reduction of transmission intensity occurs using image data provided by the image sensor.
Dependencies are inferred from the claim text.