Fusion protein for remodeling antibody glycoform
AssigneeCho Pharma, Inc.
InventorsKuo-Ching CHU, Lin-Ya HUANG, Yi-Fang ZENG
Life of this patent
Estimating the term…
Abstract
The present disclosure provides a fusion protein comprising a fucosidase or a truncated fragment or a mutant thereof fuses with either N-terminal end or C-terminal end of the endoglycosidase or a truncated fragment of mutant thereof. The present disclosure also provides a nucleic acid molecule expressing the fusion protein and a method for remodeling a glycan of an antibody Fc region.
Claims21
A fusion protein comprising a fucosidase or a truncated fragment or a mutant thereof fuses with either N-terminal end or C-terminal end of an endoglycosidase or a truncated fragment or a mutant thereof wherein the fusion protein exhibits both the fucosidase activity and the endoglycosidase activity.
Dependencies are inferred from the claim text.