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US 2021/0038697 A1Published application
Virus-like nanocapsid for oral delivery of insulin
AssigneeThe Regents of the University of California
InventorsR. Holland CHENG, Chun Chieh Chen, Mohammad Ali Baikoghli
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Abstract
Hepatitis E vims (HEV)-based virus like particles (VLP) made with a modified capsid protein containing at least a portion of open reading frame 2 (ORF2) protein and encapsulated insulin protein or insulin encoding nucleic acid are provided. Also provided are methods of targeted delivery of insulin using the HEV VLP.
Claims16
A composition comprising:
- (a) a modified capsid protein that comprises at least a portion of hepatitis E virus (HEV) open Reading Frame 2 (ORF2) protein and is able to form an HEV virus like particle (VLP);
- and
- (b) an insulin protein or a nucleic acid encoding an insulin protein encapsulated within the HEV VLP formed by the modified capsid protein.
Dependencies are inferred from the claim text.