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US 2021/0011024 A1Published application
Methods for discovering therapeutic targets
AssigneeArizona Board of Regents on behalf of Arizona State University
InventorsStephen Albert Johnston, Joseph Barten Legutki, Muskan Kukreja
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Abstract
Disclosed are methods and devices to provide efficient methods and systems for discovering therapeutic targets, novel antigens, and for deciphering an immunosignature. The invention discloses methods for the identification of unique peptides which form an immunosignature. The invention can be applied to target identifying screening in drug discovery.
Claims15
A method of identifying vaccine targets comprising:
- contacting a peptide array with a first biological sample from an individual with a known infection of interest;
- detecting binding of antibodies in the first biological sample with the peptide array to obtain a first immunosignature profile;
- contacting the same type of peptide array with a control sample derived from an individual without the known infection;
- detecting binding of antibody in the control sample with the same type of peptide array to obtain a second immunosignature profile;
- comparing the first immunosignature profile to the second immunosignature profile and identifying differentially bound peptides that either bind less or more antibody in the first immunosignature profile as compared to the second immunosignature profile;
- and
- identifying proteins that correspond to the identified differentially bound peptides as vaccine targets for the condition of interest.
4 more elements
Dependencies are inferred from the claim text.