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US 2021/0009504 A1Published application
Methods for producing (6s,15s)-3,8,13,18-tetraazaicosane-6,15-diol
AssigneeSun BioPharma, Inc.
InventorsP. Sathya Shanker, Sankappa Rai U, Murali Venghatraghavan, Selvam Vengatesan, Rahul Patil, Padavalachandu Bharathkumar
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Abstract
The present invention provides methods of synthesizing (6S,15S)-3,8,13,18-tetraazaicosane-6,15-diol and salts thereof.
Claims17
A method of producing Compound 1 or a salt thereof,
- comprising the steps of:
- (a) reacting a compound of Formula (I),
- wherein each PG is an amino protecting group,
- with a compound of Formula (II),
- wherein X is a leaving group;
- thereby producing a compound of Formula (III),
- (b) reacting the compound of Formula (III) with a reducing agent, thereby producing a compound of Formula (IV),
- (c) reacting the compound of Formula (IV) with an acetylating agent thereby producing a compound of Formula (V),
- (d) reacting the compound of Formula (V) with a reducing agent, thereby producing a compound of Formula (VI),
- and
- (e) deprotecting the compound of Formula (VI), optionally in the presence of an acid, thereby producing Compound 1 or a salt thereof.
8 more elements
Dependencies are inferred from the claim text.