T cell receptor fusions and conjugates and methods of use thereof
AssigneeAltor BioScience Corporation
InventorsHing C. Wong, Peter Rhode, Xiaoyun Zhu
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Abstract
Featured is T cell receptor complexes designed to redirect the immune system against various diseases. The T cell receptor complexes of the invention have been engineered to recognize target antigen in a functionally bispecific nature. Fusion protein complexes and protein conjugate complexes are comprised of high affinity antigen-specific TCR and biologically active proteins and/or effector molecules. Also featured is methods of production of T cell receptor fusion and conjugate complexes as well as therapeutic compositions for use of the complexes.
Claims9
1-97. (canceled)
A method of treating cancer in a subject in need thereof, the method comprising:
- administering to the subject an effective amount of an IL-2 fusion protein and cisplatin, wherein the IL-2 fusion protein comprises a T cell receptor (TCR).
Dependencies are inferred from the claim text.