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AssigneeTsinghua University
InventorsYonghui ZHANG, Xiaoying ZHOU, Hongying XIAO, Yun XIA, Yonghua XIE, Zhengsen YU
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Provided in the present invention is the use of a mevalonic acid pathway inhibitor in the preparation of a drug for treating and/or preventing tumours, inducing immunogenic death of tumour cells, inducing immune responses and activating T cells or DC cells to directly promote host immunity. Also provided in the present invention is a pharmaceutical composition comprising the mevalonic acid pathway inhibitor and an antitumour drug (for example, an immune checkpoint inhibitor and any drug that can lead to new antigen production) and a combination of the mevalonic acid pathway inhibitor and an antitumour drug (for example, an immune checkpoint inhibitor and any drug that can lead to new antigen production) and/or the radiotherapy.
-12. (canceled)
A method of treating a tumor, comprising administering to a subject in need thereof:
A method of treating a tumor, comprising infusing DC cells into a subject in need thereof, wherein said DC cells have been treated with a mevalonate pathway inhibitor.
Dependencies are inferred from the claim text.