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US 2021/0003530 A1Published application
Systems and methods for sample preparation, processing and analysis
AssigneeIntegenX Inc.
InventorsAlexander Kindwall, Chungsoo Charles Park, Fedor IIkov, Stevan Jovanovich, David King, Tristan Robert Littlehale, David Grant Nilson, Rick Pittaro, Robert A. Schueren, Mattias Vangbo, Philip Justus Wunderle
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Abstract
The present disclosure provides systems and methods for sample preparation, processing and analysis. Also provided in the present disclosure is a fully-integrated electrophoresis cartridge which has a small footprint and configured to removably engage with the system.
Claims20
An electrophoresis cartridge, comprising:
- an integrated electrophoresis assembly including:
- (1) an anode sub-assembly comprising an anode,
- (2) a cathode sub-assembly comprising a cathode;
- and
- (3) at least one electrophoresis capillary having a first end and a second end,
- wherein said cathode and said anode provide a voltage gradient between said first end and said second end of said at least one capillary.
3 more elements
A method, comprising:
- (a) providing a system comprising an electrophoresis cartridge interface that releasably engages with an electrophoresis cartridge comprising (1) an anode sub-assembly comprising an anode;
- (2) a cathode sub-assembly comprising a cathode;
- and (3) at least one electrophoresis capillary that is in fluid communication with said anode and said cathode;
- (b) receiving said electrophoresis cartridge at said electrophoresis cartridge interface;
- and
- (c) automatically establishing at least one of (i) an optical communication between an optical detection assembly of said system and a portion of said at least one electrophoresis capillary, (ii) an electrical communication between said system and said anode and said cathode, (iii) a fluidic communication between said system and said at least one electrophoresis capillary, (iv) a thermal communication between said system and said electrophoresis cartridge or said at least one electrophoresis capillary;
- (v) an electromagnetic communication between said system and said electrophoresis cartridge and (vi) a magnetic communication between said system and said electrophoresis cartridge.
4 more elements
A system, comprising:
- (a) a sample cartridge interface that engages with a sample cartridge;
- (b) a sample preparation module that (1) performs sample analysis on a sample from said sample cartridge to produce an analyte and (2) directs said analyte to a sample outlet port, which analysis is performed when said sample cartridge is engaged with said sample cartridge interface;
- and
- (c) an electrophoresis cartridge interface that is releasably engageable with an electrophoresis cartridge including an integrated electrophoresis assembly having (1) an anode sub-assembly comprising an anode, (2) a cathode sub-assembly comprising a cathode, and (3) at least one electrophoresis capillary having a first end and a second end, wherein said cathode and said anode provide a voltage gradient between said first end and said second end of said at least one capillary,
- wherein said electrophoresis cartridge interface is engageable with said electrophoresis cartridge to automatically establish at least one of:
- (i) an optical communication between said system and a portion of said at least one electrophoresis capillary,
- (ii) an electrical communication between said electrophoresis system and said anode and said cathode,
- (iii) a fluidic communication between said electrophoresis system and said at least one electrophoresis capillary,
- (iv) a thermal communication between said electrophoresis system and said at electrophoresis cartridge or said at least one electrophoresis capillary;
- (v) an electromagnetic communication between said system and said electrophoresis cartridge and
- (vi) a magnetic communication between said system and said electrophoresis cartridge.
8 more elements
Dependencies are inferred from the claim text.