Cd153 and/or cd30 in infection
AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsDaniel L. Barber, Michelle A. Sallin, Keith D. Kauffman, Taylor Foreman
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Abstract
In an embodiment, the invention provides a method of diagnosing infection in a subject. In an embodiment, the invention provides a method of determining the latency of infection in a subject. In an embodiment, the invention provides a method of determining the effectiveness of a vaccine against infection in a subject. In an embodiment, the invention provides a method of determining the severity of infection in a subject. In an embodiment, the invention provides a method of preventing or treating infection in a subject.
Claims26
A method of diagnosing infection in a subject, the method comprising:
- (a) obtaining a biological sample from the subject;
- (b) detecting the expression level of CD153 or CD30 in the sample;
- and
- (c) diagnosing the subject with infection when the expression level of CD153 or CD30 in the sample is detected to be higher compared to the expression level of CD153 or CD30 in a subject without infection.
-3. (canceled)
(canceled)
-31. (canceled)
A method of determining the severity of infection in a subject, the method comprising:
- (a) obtaining a biological sample from the subject;
- (b) detecting the expression level of CD153 or CD30 in the sample;
- and
- (c) determining the infection to be less severe when the expression level of CD153 or CD30 in the sample is detected to be higher compared to the expression level of CD153 or CD30 in a subject with active infection.
-34. (canceled)
(canceled)
-48. (canceled)
A method of preventing or treating infection in a subject, the method comprising administering to the subject an effective amount of CD4 T cells induced to upregulate CD153.
(canceled)
Dependencies are inferred from the claim text.