Methods and Compositions for Modulating TH-GM Cell Function
AssigneeNational University of Singapore
InventorsXin-yuan FU, Wanqiang SHENG, Yongliang ZHANG, Fan YANG
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Abstract
Disclosed herein is a T-helper cell (“TH-GM” cell) that is regulated by IL-7/STAT5 and which secrete GM-CSF/IL-3. Also disclosed are methods and compositions for modulating TH-GM function for the treatment of, e.g., inflammatory disorders. Diagnostic and prognostic methods for specifically identifying TH-GM-mediated inflammatory disorders (e.g., rheumatoid arthritis), as distinct from and/or in addition to non-TH-GM-mediated (e.g., TNF-α-mediated) inflammatory disorders, are also provided.
Claims20
-33. (canceled)
A method of treating an inflammatory disease associated with a TNF-α-independent inflammatory pathway, comprising administering to a subject in need thereof an effective amount of a signal transducer and activator of transcription 5 (STAT5) inhibitor, wherein the inflammatory disease is mediated by granulocyte macrophage colony-stimulating factor (GM-CSF)-secreting T-helper (Th-GM) cells, wherein the STAT5 inhibitor reduces serum level of GM-CSF in the subject and thereby providing a therapeutic benefit to the subject in a TNF-α-independent manner.
A method of treating rheumatoid arthritis, comprising administering to a subject in need thereof an effective amount of (A) a STAT5 inhibitor and (B) a therapeutic agent that inhibits the TNF-α inflammatory pathway.
Dependencies are inferred from the claim text.