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US 2020/0407696 A1Published application
Baculovirus expression system
AssigneeHaifeng Chen
InventorHaifeng Chen
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Abstract
The present disclosure relates to a heterologous recombinant baculovirus (rBV) expression system for the production of foreign heterologous proteins in insect cells. This system comprises a recombinant baculovirus backbone within a genome with a deletion in the cathepsin gene into which foreign gene cassettes can be integrated, and an insect cell that can be infected by the Δv-cath-rBV, and in which the foreign proteins and/or viral vectors or particles are expressed.
Claims28
A recombinant baculovirus (rBV) DNA backbone, comprising:
- a chitinase gene
- a deletion of the v-cath gene;
- and
- a DNA fragment enabling integration of one or more foreign protein expression cassettes into the backbone such that the one or more foreign protein or proteins expressed in the insect cell is less degraded than it is when expressed from an rBV backbone without the deletion.
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