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US 2020/0405802 A1Published application
Novel multi-functional peptides and use thereof
AssigneeNovacell Technology Inc.
InventorsTae Hoon LEE, Jae Wang GHIM, Hyun Ju LEE
Life of this patent
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Abstract
The present invention provides a novel multi-functional peptide that effectively regulates the activity of immune cells while also exhibiting excellent antibacterial activity against various bacteria such as Gram-negative bacteria and Gram-positive bacteria.
Claims17
A peptide having antibacterial and immunomodulatory activity which consists of 6 to 12 amino acids comprising an amino acid sequence selected from the group consisting of:
- i) BOBWX1OU;
- and
- ii) X1RWWUX1X2m
- wherein
- B is a basic amino acid independently selected from the group consisting of lysine (K) and arginine (R),
- O is an aromatic amino acid independently selected from the group consisting of phenylalanine (F), tyrosine (Y), and tryptophan (W),
- X1 is independently selected from the group consisting of arginine (R), norleucine (Nle) and 2-naphthyl-L-alanine (Z),
- U is absent or selected from the group consisting of m, X2WW, RX2WW and MVm, wherein X2 is selected from the group consisting of norleucine (Nle), tryptophan (W), and valine (V), and m is D-type methionine,
- with the proviso that BOBWX1OU is not KFKWRYm.
6 more elements
Dependencies are inferred from the claim text.