Injectable composition for preventing hair loss or stimulating hair growth
AssigneeKeramedix Inc.
InventorsYu-Shik HWANG, Il-Keun KWON, So Yeon KIM, Se Young VAN
Life of this patent
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Abstract
The present invention relates to an injectable pharmaceutical composition containing keratin for preventing hair loss or stimulating hair growth, wherein the composition is excellent in hair follicle generating and hair growth stimulating effects, and thus can be favorably used as a preventive and therapeutic agent for hair loss or a stimulating agent for hair growth.
Claims10
1-13. (canceled)
An injectable pharmaceutical composition comprising keratin for stimulating hair growth and regenerating dermal papilla,
- wherein the keratin has a molecular weight of 500 to 70,000 Daltons by disulfide bond degradation or peptide degradation.
The injectable pharmaceutical composition of claim 1, wherein the pharmaceutical composition increases an expression level of at least one selected from the group consisting of beta-catenin, Sox-9, Sox-2, alkaline phosphatase, CD133, FGF7, FGF10, BMP6, P-cadherin, E-cadherin, MSX2, FOXN1 and CD10.
The injectable pharmaceutical composition of claim 1, wherein the pharmaceutical composition is administered to the dermal layer or the subcutaneous tissue.
The injectable pharmaceutical composition of claim 1, further comprising:
- a penetration enhancer.
The injectable pharmaceutical composition of claim 8, wherein the penetration enhancer is at least one selected from the group consisting of sulphoxide, azone, pyrrolidone, fatty acids, lower alcohols having 1 to 4 carbon atoms, higher fatty alcohols having 6 or more carbon atoms, glycols, urea, terpene, terpenoid, and phospholipid.
The injectable pharmaceutical composition of claim 1, wherein the keratin is the keratin by the peptide degradation prepared by a preparation method, including S1) reacting keratin with hydrolase;
- and S2) removing the hydrolase.
The injectable pharmaceutical composition of claim 10, wherein the hydrolase is at least one selected from the group consisting of Proteinase-K, Leucyl aminopeptidase, carboxypeptidase, pepsin, trypsin, and chymotrypsin.
The injectable pharmaceutical composition of claim 10, wherein the hydrolase is immobilized on beads.
The injectable pharmaceutical composition of claim 10, wherein the preparation method further includes S3) removing the activity of the hydrolase after step S2).
Dependencies are inferred from the claim text.