# US 2020/0401653 A1 · Method and apparatus for calibration and testing of scientific measurement equipment > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2020/0401653 A1 - Document ID: US20200401653A1 - Status: Published application - Kind: A1 - Application number: 16/450,380 - Filed: 2019-06-24 - Published: 2020-12-24 - Earliest claimed: 2009-07-21 - Assignees: Ccqcc Corp. - Applicants: CCQCC Corp. - Inventors: George S. Cembrowski; David Vu Tran - Web page: https://patentgrep.com/patent/US20200401653A1 ## CPC - G06F 17/18: for evaluating statistical data {, e.g. average values, frequency distributions, probability functions, regression analysis (forecasting specially adapted for a specific administrative, business or logistic context G06Q10/04)} - G01N 33/49: Blood {(chemical methods for determining blood cell populations G01N33/5094; chemical analysis of blood groups or blood types G01N33/80)} - G01N 35/00693: {Calibration} - G01N 35/00871: {Communications between instruments or with remote terminals} - G01N 2035/00653: {statistical methods comparing labs or apparatuses} - G06F: ELECTRIC DIGITAL DATA PROCESSING (computer systems based on specific computational models G06N) - G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q) ## Abstract Discussed herein are systems, methods, and apparatuses for quality control monitoring of laboratory analyzers. A method can include receiving test results from laboratory analyzers, the test results corresponding to a same analyte, determining a standard deviation of differences (SDD) among pairs of the multiple test results, calibrating the laboratory analyzer based on the determined SDD. ## Claims ### Claim 1 A method for calibration of a laboratory analyzer comprising: receiving test results from laboratory analyzers, the test results corresponding to a same analyte; determining a standard deviation of differences (SDD) among pairs of the multiple test results; calibrating the laboratory analyzer based on the determined SDD; and wherein the calibrated laboratory analyzer is used to generate further test results. ### Claim 2 (depends on 1) The method of claim 1 further comprising, before determining the SDD, filtering the test results based on a laboratory analyzer identification, and wherein determining the analytic variation includes determining the analytic variation for each laboratory analyzer of the multiple laboratory analyzers, and comparing the SDDs to identify a laboratory analyzer of the multiple laboratory analyzers to be calibrated. ### Claim 3 (depends on 1) The method of claim 1 further comprising, before determining the SDD, filtering the test results based on a facility identification uniquely indicating a facility of facilities that houses the laboratory analyzer, and wherein determining the analytic variation includes determining the analytic variation for each facility of the facilities, and comparing the SDDs to identify a facility of the multiple facilities that generates worse test results. ### Claim 4 (depends on 3) The method of claim 3, further comprising obtaining the test results by data-mining previous results provided by the laboratory analyzer. ### Claim 5 (depends on 1) The method of claim 1, further comprising grouping the test results by a time interval in which the sample results were provided, and wherein calculating the SDD variation includes calculating the SDD for each time interval. ### Claim 6 (depends on 1) The method of claim 1, further comprising removing out-lying test results before determining the SDD. ### Claim 7 (depends on 6) The method of claim 6, wherein removing out-lying test results includes removing out-lying test results as a function of a frequency histogram and removing to test results from a repeated measurement made within a specific time period. ### Claim 8 (depends on 6) The method of claim 6, wherein removing out-lying test results includes removing test results from a repeated measurement made within two hours. ### Claim 9 A system comprising: multiple laboratory analyzers that perform measurements on one or more analytes to generate test results; a memory storing the test results; a processor communicatively coupled to the memory; the memory storing instructions, which when executed by the processor, cause the processor to perform operations comprising: receiving test results from laboratory analyzers; determining a standard deviation of differences (SDD) among pairs of the multiple test results; and causing the laboratory analyzer to be calibrated based on the determined SDD so the calibrated laboratory analyzer can be used to generate calibrated test results. ### Claim 10 (depends on 9) The system of claim 9, wherein the operations further comprise, before determining the SDD, filtering the test results based on a laboratory analyzer identification, and wherein determining the analytic variation includes determining the analytic variation for each laboratory analyzer of the multiple laboratory analyzers, and comparing the SDDs to identify a laboratory analyzer of the multiple laboratory analyzers to be calibrated. ### Claim 11 (depends on 9) The system of claim 9, wherein the operations further comprise, before determining the SDD, filtering the test results based on a facility identification uniquely indicating a facility of facilities that houses the laboratory analyzer, and wherein determining the analytic variation includes determining the analytic variation for each facility of the facilities, and comparing the SDDs to identify a facility of the multiple facilities that generates worse test results. ### Claim 12 (depends on 11) The system of claim 11, wherein the operations further comprise obtaining the test results by data-mining previous results provided by the laboratory analyzer. ### Claim 13 (depends on 9) The system of claim 9, wherein the operations further comprise grouping the test results by a time interval in which the sample results were provided, and wherein calculating the SDD variation includes calculating the SDD for each time interval. ### Claim 14 (depends on 9) The system of claim 9, wherein the operations further comprise removing out-lying test results before determining the SDD. ### Claim 15 (depends on 14) The system of claim 14, wherein the operations further comprise removing out-lying test results includes removing out-lying test results as a function of a frequency histogram and removing test results from a repeated measurement made within a specific time period. ### Claim 16 (depends on 14) The system of claim 14, wherein the operations further comprise removing out-lying test results includes removing test results from a repeated measurement made within two hours.