Biomarkers for the early detection of breast cancer

A polypeptide probe set comprising:

• at least 2 different isolated polypeptides selected from the group consisting of ATP6AP1 (SEQ ID NO:
• 13), PDCD6IP (SEQ ID NO:
• 21), DBT (SEQ ID NO:
• 25), CSNK1E (SEQ ID NO:
• 9), FRS3 (SEQ ID NO:
• 3), HOXD1 (SEQ ID NO:
• 7), SF3A1 (SEQ ID NO:
• 1), C15orf48 (SEQ ID NO:
• 35), MYOZ2 (SEQ ID NO:
• 33), BAT4 (SEQ ID NO:
• 5), BMX (SEQ ID NO:
• 45), RAB5A (SEQ ID NO:
• 23), UBAP1 (SEQ ID NO:
• 47), GPR157 (SEQ ID NO:
• 43), ZMYM6 (SEQ ID NO:
• 41), SLC33A1 (SEQ ID NO:
• 11), TRIM32 (SEQ ID NO:
• 37), ALG10 (SEQ ID NO:
• 27), TFCP2 (SEQ ID NO:
• 49), SERPINH1 (SEQ ID NO:
• 51), SELL (SEQ ID NO:
• 55), ZNF510 (SEQ ID NO:
• 53), or antigenic fragments thereof;
• wherein the probe set comprise no more than 100 different polypeptides.

A polynucleotide array comprising:

• (a) a support;
• and
• (b) at least 2 different isolated nucleic acids encoding polypeptides selected from the group consisting of ATP6AP1 (SEQ ID NO:
• 14), PDCD6IP (SEQ ID NO:
• 22), DBT (SEQ ID NO:
• 26), CSNK1E (SEQ ID NO:
• 10), FRS3 (SEQ ID NO:
• 4), HOXD1 (SEQ ID NO:
• 8), SF3A1 (SEQ ID NO:
• 2), C15orf48 (SEQ ID NO:
• 36), MYOZ2 (SEQ ID NO:
• 34), BAT4 (SEQ ID NO:
• 6), BMX (SEQ ID NO:
• 46), RAB5A (SEQ ID NO:
• 24), UBAP1 (SEQ ID NO:
• 48), GPR157 (SEQ ID NO:
• 44), ZMYM6 (SEQ ID NO:
• 42), SLC33A1 (SEQ ID NO:
• 12), TRIM32 (SEQ ID NO:
• 38), ALG10 (SEQ ID NO:
• 28), TFCP2 (SEQ ID NO:
• 50), SERPINH1 (SEQ ID NO:
• 52), SELL (SEQ ID NO:
• 56), ZNF510 (SEQ ID NO:
• 54), or antigenic fragments thereof, attached to the support wherein the array comprise no more than 100 different isolated nucleic acids.