# US 2020/0399292 A1 · Composition for substrate surface modification and method using the same

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- Number: US 2020/0399292 A1
- Document ID: US20200399292A1
- Status: Published application
- Kind: A1
- Application number: 17/011,390
- Filed: 2020-09-03
- Published: 2020-12-24
- Earliest claimed: 2018-08-07
- Assignees: National Central University
- Applicants: National Central University
- Inventors: Chen-Han HUANG; Wen-Hao CHEN
- Web page: https://patentgrep.com/patent/US20200399292A1

## CPC

- C07F 7/10: containing nitrogen {having a Si-N linkage}
- C12N 11/14: Enzymes or microbial cells immobilised on or in an inorganic carrier
- C09D 5/1662: {Synthetic film-forming substance}
- C12N 11/02: Enzymes or microbial cells immobilised on or in an organic carrier
- C12N 11/06: attached to the carrier via a bridging agent
- C12N 11/08: the carrier being a synthetic polymer
- C07K 17/06: attached to the carrier via a bridging agent
- C07K 17/08: the carrier being a synthetic polymer
- C07K 17/14: Peptides being immobilised on, or in, an inorganic carrier
- C07F: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM (metal-containing porphyrins C07D487/22)
- C12N: MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media C12Q1/00)
- C09D: COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR (cosmetics A61K; processes for applying liquids or other fluent materials to surfaces, in general, B05D; staining wood B27K5/02; glazes or vitreous enamels C03C; natural resins, French polish, drying-oils, driers, turpentine, per se, C09F; polishing compositions other than French polish, ski waxes C09G; adhesives or use of materials as adhesives C09J; materials for sealing or packing joints or covers C09K3/10; materials for stopping leaks C09K3/12; processes for the electrolytic or electrophoretic production of coatings C25D)
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)

## Abstract

The present invention provides a composition for substrate surface modification and a method using the same, and the composition for substrate surface modification is composed of a compound of the general formula structure shown in formula 1: formula 1, wherein n1 is an integer of 1 to 6, and R is a zwitterionic group. The composition for substrate surface modification uses water as a medium to perform modifying reaction over a substrate surface, and at the same time has biological modification characteristics, and abilities of immobilizing biomolecules and anti-biofouling.

## Claims

### Claim 1

A composition for substrate surface modification, comprising a compound described in formula 1:
formula 1, wherein n1 is an integer of 1 to 6, and R is a zwitterionic group, wherein the composition for substrate surface modification is attached to a substrate surface by water to modify the substrate surface.

### Claim 2 (depends on 1)

The method of using the composition for substrate surface modification as claimed in claim 1, wherein the substrate is a metal, a polymer or a glass.