# US 2020/0399277 A1 · [1,2,4]triazolo[4,3-a]pyrazin-8-one derivatives

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 2020/0399277 A1
- Document ID: US20200399277A1
- Status: Published application
- Kind: A1
- Application number: 16/956,826
- Filed: 2019-01-13
- Published: 2020-12-24
- Earliest claimed: 2018-02-06
- Assignees: Eli Lilly and Company
- Applicants: Eli Lilly and Company
- Inventors: Nicholas Paul CAMP; Chafiq HAMDOUCHI; Jayana Pankaj LINESWALA; John Richard MORPHY; Qing SHI
- Web page: https://patentgrep.com/patent/US20200399277A1

## CPC

- C07D 487/04: Ortho-condensed systems
- A61P 13/12: of the kidneys
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention provides a compound of Formula I: wherein R1 is methyl, ethyl or cyclopropyl; R2 is hydrogen, methyl, or ethyl; R3 is methyl or AA; and R4 is C2-C4 alkyl, BB; or a pharmaceutically acceptable salt thereof; for use as a PDE1 inhibitor.

## Claims

### Claim 1

A compound of the formula:
wherein R1 is methyl, ethyl or cyclopropyl;
R2 is hydrogen, methyl, or ethyl;
R3 is methyl or
and
R4 is C2-C4 alkyl,
or a pharmaceutically acceptable salt thereof.

### Claim 2 (depends on 1)

The compound or salt according to claim 1 wherein R1 is cyclopropyl.

### Claim 3 (depends on 1)

The compound or salt according to claim 1 wherein R2 is methyl.

### Claim 4 (depends on 1)

The compound or salt according to claim 1 wherein R3 is methyl.

### Claim 5 (depends on 1)

The compound or salt according to claim 1 wherein the compound is:

### Claim 6 (depends on 1)

The compound or salt according to claim 1 wherein the compound is:

### Claim 7 (depends on 1)

The compound or salt according to claim 1 wherein the compound is:

### Claim 8 (depends on 1)

The compound or salt according to claim 1 wherein the compound is:

### Claim 9 (depends on 1)

A method of treating chronic kidney disease in a patient, comprising administering to a patient in need thereof an effective amount of a compound according to claim 1, or a pharmaceutically-acceptable salt thereof.

### Claim 10 (depends on 1)

A method of treating diabetic kidney disease in a patient, comprising administering to a patient in need thereof an effective amount of a compound according to claim 1, or a pharmaceutically-acceptable salt thereof.

### Claim 11

(canceled)

### Claim 12

(canceled)

### Claim 13

(canceled)

### Claim 14 (depends on 1)

A pharmaceutical composition, comprising a compound or a pharmaceutically-acceptable salt thereof according to claim 1, with one or more pharmaceutically acceptable carriers, diluents, or excipients.

### Claim 15 (depends on 1)

A process for preparing a pharmaceutical composition, comprising admixing a compound according to claim 1, or a pharmaceutically-acceptable salt thereof, with one or more pharmaceutically acceptable carriers, diluents, or excipients.