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US 2020/0397925 A1Published application
Targeted protein contrast agents, methods of making, and uses thereof
AssigneeGeorgia State University Research Foundation, Inc.
InventorsJenny Jie YANG, Fan PU, Shenghui XUE, Jingjuan QIAO, Shanshan TAN, Mani SALARIAN
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Abstract
Provided herein are protein contrast agents and targeted protein contrast agents, formulations thereof, and methods of use, including but not limited to, as a magnetic resonance imaging contrast agent.
Claims9
1-48. (canceled)
A protein contrast agent comprising:
- a parvalbumin polypeptide, wherein the parvalbumin polypeptide has the amino acid sequence according to SEQ ID NO. 10 comprising SEQ ID NO.:
- 10, wherein the parvalbumin polypeptide contains a paramagnetic metal binding site consisting of one or more amino acid residues of SEQ ID NO. 10, and wherein the parvalbumin polypeptide comprising SEQ ID NO.:
- 10 further comprises a C-X-C chemokine receptor type 4 (CXCR-4)-targeting moiety directly fused or indirectly linked via a flexible peptide linker to a terminus of the parvalbumin polypeptide.
Dependencies are inferred from the claim text.