Composition of subunit dengue vaccine
AssigneeNational Cheng Kung University
InventorsYee-Shin Lin, Trai-Ming Yeh, Yung-Chun Chuang, Chia-Yi Yu, Hsin-Wei Chen, Shu-Wen Wan, Shu-Ying Wang, Tzong-Shiann Ho, Dar-Bin Shieh
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Abstract
The present invention relates to a composition of subunit dengue vaccine comprising a fusion protein of conjugating or connecting delta C nonstructural protein 1 (NS1ΔC or truncated NS1ΔC) to at least one polypeptides of NS3c (or truncated NS3c) and/or consensus envelope protein domain III (cEDIII), thereby enhancing better protection against DENV challenge and alleviating associated pathological effects.
Claims19
A composition of subunit dengue vaccine, comprising:
- a fusion protein of a delta C nonstructural protein 1 (NS1ΔC) polypeptide conjugating or connecting to at least one polypeptides of a NS3c polypeptide and/or a consensus envelope protein domain III (cEDIII) polypeptide, wherein the NS1ΔC polypeptide is listed as SEQ ID NOs:
- 2 or 5, the cEDIII polypeptide is listed as SEQ ID NOs:
- 1 or 4, and the NS3c polypeptide is listed as SEQ ID NOs:
- 3 or 6;
- and
- optionally together with one or more pharmaceutically acceptable carriers and/or adjuvants.
A composition of subunit dengue vaccine, comprising:
- a fusion protein including a cEDIII polypeptide and a NS1ΔC polypeptide, wherein the cEDIII polypeptide is listed as SEQ ID NOs:
- 1 or 4, the NS1ΔC polypeptide is listed as SEQ ID NOs:
- 2 or 5;
- a NS3c polypeptide including SEQ ID NOs:
- 3 or 6;
- and
- optionally together with one or more pharmaceutically acceptable carriers and/or adjuvants.
A composition of subunit dengue vaccine, comprising:
- a fusion protein of truncated NS1 polypeptide of SEQ ID NOs:
- 5 and truncated NS3c polypeptide of SEQ ID NOs:
- 6, and optionally together with one or more pharmaceutically acceptable carriers and/or adjuvants.
Dependencies are inferred from the claim text.