Method for increasing neprilysin expression and activity
OwnerDenis G. Kay, Jackalina M. Vas Kampeninventors
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Abstract
This invention is directed to methods and compositions for increasing the expression or activity of neprilysin in, for example, the frontal cortex or the entorhinal cortex using a progranulin polypeptide or effector. The present invention is further directed to methods of reducing microglia in the brain of a patient with neurodegenerative disease using a progranulin polypeptide or effector.
Claims6
A method for increasing the activity of neprilysin in the frontal cortex or entorhinal cortex of a patient with neurodegenerative disease, the method comprising the step of
- administering to the patient a composition comprising a progranulin polypeptide wherein the activity of neprilysin in the frontal cortex or entorhinal cortex of the patient is increased.
(canceled)
A method for increasing the activity of neprilysin in the frontal cortex or entorhinal cortex of a patient with neurodegenerative disease, the method comprising the step of
- administering to the patient a composition comprising an effector that modifies progranulin expression wherein the activity of neprilysin in the frontal cortex or entorhinal cortex of the patient is increased.
4-6. (canceled)
A method for increasing the activity or expression of neprilysin in the brain of an individual without a neurodegenerative disease to prevent the neurodegenerative disease, the method comprising the step of
- administering to the individual a composition comprising a progranulin polypeptide wherein the neurodegenerative disease is prevented.
8-23. (canceled)
Dependencies are inferred from the claim text.