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US 2020/0384061 A1Published application
Fusion Protein Including BDNF
AssigneeJCR Pharmaceuticals Co., Ltd.
InventorsHiroyuki Sonoda, Kenichi Takahashi
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Abstract
The present invention provides a fusion protein of BDNF and an anti-human transferrin receptor antibody, in which in a heavy chain variable region of the antibody, (a) CDR1 includes an amino acid sequence of SEQ ID NO: 66 or SEQ ID NO: 67, (b) CDR2 includes an amino acid sequence of SEQ ID NO: 13 or SEQ ID NO: 14, and (c) CDR3 includes an amino acid sequence of SEQ ID NO: 15 or SEQ ID NO: 16.
Claims88
A fusion protein of brain-derived neurotrophic factor (BDNF) and an anti-human transferrin receptor antibody,
- wherein in a heavy chain variable region of the antibody,
- (a) CDR1 includes an amino acid sequence of SEQ ID NO:
- 66 or SEQ ID NO:
- 67,
- (b) CDR2 includes an amino acid sequence of SEQ ID NO:
- 13 or SEQ ID NO:
- 14, and
- (c) CDR3 includes an amino acid sequence of SEQ ID NO:
- 15 or SEQ ID NO:
- 16.
7 more elements
(canceled)
(canceled)
Dependencies are inferred from the claim text.